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(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(m-tolyl)propanoic acid

  • CAS No. 501015-27-6

  • Cat. No. CS-0181512
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(m-tolyl)propanoic acid|CS-0181512

Structure of 501015-27-6

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General Information

  • CAS No. 501015-27-6
  • Cat. No. CS-0181512
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₃NO₄
  • Molecular Weight 401.45
  • Synonym(s) Fmoc-S-3-Amino-3-(3-methyl-phenyl)-propionic acid
  • SMILES O=C(O)C[C@H](NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C4=CC=CC(C)=C4

Description

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(m-tolyl)propanoic acid is a chiral, bench-stable amino acid derivative featuring a fluorenylmethoxycarbonyl (Fmoc) protecting group and a sterically hindered m-tolyl side chain. This structure enables efficient incorporation into peptide synthesis workflows while maintaining high enantiomeric purity and compatibility with standard coupling conditions.

Application

(S)-3-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(m-tolyl)propanoic acid serves as a robust chiral building block for peptide synthesis, offering high diastereoselectivity in amide bond formation. The Fmoc group enables convenient orthogonal protection and facile removal under mild basic conditions, while the meta-tolyl side chain provides steric and electronic stability. Its bench-stable nature and compatibility with standard coupling protocols make it ideal for solid-phase and solution-phase peptide assembly.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   5.04952
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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