CRBN ligand-224

Name: CRBN ligand-224
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CAS No. 2599846-40-7
Cat. No. CS-0369470
Molecule weight234.21
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Structure of 2599846-40-7

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General Information

CAS No. 2599846-40-7
Cat. No. CS-0369470
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₁H₁₀N₂O₄
Molecular Weight 234.21
Synonym(s) None
SMILES O=C(O)C1=CC=C(C=C1)N2C(=O)NC(=O)CC2

Description

4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)benzoic acid features a conjugated pyrimidinone core linked to a benzoic acid moiety, enabling integration into bioactive scaffolds. The electron-deficient heterocycle pairs with the carboxylic acid group to facilitate coupling reactions and enhance solubility in polar media. This structure supports applications in medicinal chemistry and molecular probe development.

Application

4-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)benzoic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to bioactive scaffolds via condensation and cyclization reactions. Its dual functionality—carboxylic acid and 2,4-dioxotetrahydropyrimidine moiety—facilitates diverse transformations under mild conditions, with excellent bench stability and straightforward purification. Functions effectively in solid-phase and solution-phase workflows for medicinal chemistry campaigns requiring modular pyrimidine integration.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

TPSA 86.71
LogP 0.8311
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 2

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Other aliphatic heterocycles compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Life Science PROTAC Ligands for E3 Ligase

Chemical Biology Pharmaceutical Development and Drug Discovery Research Reagents Proteolysis Targeting Chimera Research Reagents

Biochemistry Pharmaceutical Development and Drug Discovery Research Proteolysis Targeting Chimera Research Reagents

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CRBN ligand-224

CAS No. 2599846-40-7

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