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CS-W001157 4
Total: USD 88.00

Hydrouracil-3-Ph-COOH

  • CAS No. 2377644-59-0

  • Cat. No. CS-0616708
  • Purity≥98%
  • MDL No.None
  • HazMat Fee +

    HazMat Fee

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it. There is a HazMat shipping fee for each item that qualifies as a dangerous good, except in the following scenarios:

    The shipment is processed through FedEx Ground under the Limited Quantity option.

    Each bottle is packed as an Excepted Quantity, with a maximum of 1g for items in class 6.1 packing group I or II, and up to 25g for all other hazardous materials.

    If shipping is charged to your FedEx account, the HazMat fee will be billed directly by the courier. Otherwise, the fee will be included on your invoice. To help you avoid the HazMat fee, we can package a 5g order of a class 6.1 packing group I or II material as five separate 1g units, and a 100g order of any other dangerous good as four 25g units. This packaging adjustment will be made unless you instruct otherwise on your purchase order. Below, you will find the fee schedule from FedEx for handling hazardous materials.

    Type
    HazMat Fee
    Excepted Quantity $0.00
    FedEx Limited Quantities Ground $0.00
    Hazmat Ground shipping $50.00+
    Inaccessible (Haz class 6.1 or 9), Domestic $68.00+
    Accessible (Haz class 3, 4, 5 or 8), Domestic $158.00+
    Inaccessible (Haz class 6.1 or 9), International $108.00+
    Accessible (Haz class 3, 4, 5 or 8), International $238.00+

    An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

    There is a HazMat shipping fee for each item that qualifies as a dangerous good. Please contact our quotation team via email to confirm the details.

*For research and further manufacturing use only, not for direct human use.

Hydrouracil-3-Ph-COOH|CS-0616708

Structure of 2377644-59-0

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Description

This benzoic acid derivative features a 2,4-dioxotetrahydropyrimidine moiety that imparts enhanced reactivity in heterocyclic synthesis. The conjugated system enables efficient integration into bioactive scaffolds, while the carboxylic acid group facilitates derivatization under mild conditions. Bench-stable and moisture-tolerant, it serves as a strategic building block for medicinal chemistry campaigns targeting kinase inhibitors and antiviral agents.

Application

3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)benzoic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrimidine-fused scaffolds via standard condensation and cyclization protocols. The ortho-substituted benzoic acid moiety provides enhanced solubility and facilitates downstream derivatization, while the 2,4-dioxotetrahydropyrimidine core exhibits predictable reactivity in amide coupling and nucleophilic addition reactions. Its bench-stable nature and compatibility with common functional groups support reliable application in medicinal chemistry and process development workflows.

General Information

  • CAS No. 2377644-59-0
  • Cat. No. CS-0616708
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O₄
  • Molecular Weight 234.21
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=CC(=C1)N2C(=O)NC(=O)CC2

Computational Chemistry Data

  • TPSA   86.71
  • LogP   0.8311
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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