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CS-W001157 4
Total: USD 88.00

Hydrouracil-3-Ph-COOH

  • CAS No. 2377644-59-0

  • Cat. No. CS-0616708
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Hydrouracil-3-Ph-COOH|CS-0616708

Structure of 2377644-59-0

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General Information

  • CAS No. 2377644-59-0
  • Cat. No. CS-0616708
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₀N₂O₄
  • Molecular Weight 234.21
  • Synonym(s) None
  • SMILES O=C(O)C1=CC=CC(=C1)N2C(=O)NC(=O)CC2

Description

This benzoic acid derivative features a 2,4-dioxotetrahydropyrimidine moiety that imparts enhanced reactivity in heterocyclic synthesis. The conjugated system enables efficient integration into bioactive scaffolds, while the carboxylic acid group facilitates derivatization under mild conditions. Bench-stable and moisture-tolerant, it serves as a strategic building block for medicinal chemistry campaigns targeting kinase inhibitors and antiviral agents.

Application

3-(2,4-Dioxotetrahydropyrimidin-1(2H)-yl)benzoic acid serves as a versatile building block for heterocyclic synthesis, enabling efficient access to pyrimidine-fused scaffolds via standard condensation and cyclization protocols. The ortho-substituted benzoic acid moiety provides enhanced solubility and facilitates downstream derivatization, while the 2,4-dioxotetrahydropyrimidine core exhibits predictable reactivity in amide coupling and nucleophilic addition reactions. Its bench-stable nature and compatibility with common functional groups support reliable application in medicinal chemistry and process development workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P260-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   86.71
  • LogP   0.8311
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   2

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