Lot numbers can be found on the outside label of a product:
7-Bromo-4-fluorobenzofuran
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CAS No. 253429-31-1
- Cat. No. CS-0042109
- Purity≥95%
- MDL No.MFCD09056781
*For research and further manufacturing use only, not for direct human use.
Structure of 253429-31-1
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General Information
- CAS No. 253429-31-1
- Cat. No. CS-0042109
- Purity ≥95%
- MDL No. MFCD09056781
- Storage 4°C
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₈H₄BrFO
- Molecular Weight 215.02
- Synonym(s) 7-Bromo-4-fluorobenzo[b]furan
- SMILES FC1=C2C=COC2=C(Br)C=C1
Description
7-Bromo-4-fluorobenzofuran is a heterocyclic building block featuring complementary halogen substituents that enable selective cross-coupling reactions. The electron-deficient aromatic core, flanked by bromo and fluoro groups at distinct positions, facilitates palladium-catalyzed transformations with high regiocontrol. This scaffold exhibits excellent stability under standard conditions and integrates readily into complex molecular architectures for medicinal chemistry and materials science applications.
Application
7-Bromo-4-fluorobenzofuran serves as a versatile building block in medicinal chemistry, enabling palladium-catalyzed cross-coupling reactions due to its complementary halogen reactivity. The bromo and fluoro substituents offer orthogonal functionalization potential, facilitating sequential derivatization. Bench-stable and readily purified by flash chromatography, it functions effectively in Suzuki, Stille, and Negishi couplings for constructing complex heterocyclic scaffolds and API intermediates.
Synthesis
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Route1
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253429-18-4 - ~52%
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In-stock
253429-31-1
References
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Venkatraman, Srikanth; Velazquez, Francisco; Gavalas, Stephen; Wu, Wanli; Chen, Kevin X.; Nair, Anilkumar G.; Bennett, Frank; Huang, Yuhua; Pinto, Patrick; Jiang, Yueheng; Selyutin, Oleg; Vibulbhan, Bancha; Zeng, Qingbei; Lesburg, Charles; Duca, Jose; Heimark, Larry; Huang, Hsueh-Cheng; Agrawal, Sony; Jiang, Chuan-Kui; Ferrari, Eric; Li, Cheng; Kozlowski, Joseph; Rosenblum, Stuart; Shih, Neng-Yang; George Njoroge Bioorganic and Medicinal Chemistry, 2014 , vol. 22, # 1 p. 447 - 458
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Route2
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664364-73-2 - ~%
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In-stock
253429-31-1
References
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EP1553074 A1, ; Page/Page column 47 ;
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Route3
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In-stock
147460-41-1 - ~%
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In-stock
253429-31-1
References
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Bioorganic and Medicinal Chemistry, , vol. 22, # 1 p. 447 - 458
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 13.14
- LogP 3.3344
- H_Acceptors 1
- H_Donors 0
- Rotatable_Bonds 0
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Key Words
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