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CS-W001157 4
Total: USD 88.00

6-Bromobenzofuran

  • CAS No. 128851-73-0

  • Cat. No. CS-W005044
  • Purity≥98%
  • MDL No.MFCD08669477

*For research and further manufacturing use only, not for direct human use.

6-Bromobenzofuran|CS-W005044

Structure of 128851-73-0

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General Information

  • CAS No. 128851-73-0
  • Cat. No. CS-W005044
  • Purity ≥98%
  • MDL No. MFCD08669477
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrO
  • Molecular Weight 197.03
  • Synonym(s) 6-Bromobenzofuran, Fandachem
  • SMILES BrC1=CC=C2C=COC2=C1

Description

6-Bromobenzofuran is a halogenated heterocyclic compound featuring a bromine atom at the 6-position of the benzofuran scaffold. This substitution imparts enhanced reactivity in cross-coupling processes, enabling efficient integration into complex molecular architectures. The molecule exhibits good stability under standard conditions and serves as a valuable intermediate in synthetic routes toward bioactive compounds and functional materials.

Application

6-Bromobenzofuran serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki, Stille, and Negishi couplings. Its bromine substituent exhibits high reactivity under standard conditions while maintaining bench stability and compatibility with diverse functional groups. This compound facilitates the construction of biaryl and heteroaryl architectures common in pharmaceutical and agrochemical scaffolds.

Synthesis

  • Route1
    • 1-Bromo-3-(2,2-diethoxyethoxy)benzene|CS-1143544
      204452-94-8
    • ~47%
    • In-stock
      6-Bromobenzofuran|CS-W005044
      128851-73-0
    • In-stock
      4-Bromobenzofuran|CS-0054114
      128868-60-0

    References

    • Phytochemistry, , vol. 96, p. 132 - 147
  • Route2
    • 1-Bromo-3-(2,2-diethoxyethoxy)benzene|CS-1143544
      204452-94-8
    • ~%
    • In-stock
      6-Bromobenzofuran|CS-W005044
      128851-73-0
    • In-stock
      7-Bromobenzofuran|CS-W019960
      133720-60-2

    References

    • US2010/280013 A1, ; Page/Page column 42 ;
  • Route3
    • null|null
      591-20-8
    • ~%
    • In-stock
      6-Bromobenzofuran|CS-W005044
      128851-73-0

    References

    • Journal of Medicinal Chemistry, , vol. 40, # 3 p. 322 - 330

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   13.14
  • LogP   3.1953
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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