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CS-W001157 4
Total: USD 88.00

4-Bromobenzofuran

  • CAS No. 128868-60-0

  • Cat. No. CS-0054114
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

4-Bromobenzofuran|CS-0054114

Structure of 128868-60-0

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General Information

  • CAS No. 128868-60-0
  • Cat. No. CS-0054114
  • Purity ≥97%
  • MDL No. None
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅BrO
  • Molecular Weight 197.03
  • Synonym(s) Benzofuran, 4-broMo-
  • SMILES BrC1=C2C=COC2=CC=C1

Description

4-Bromobenzofuran is a bench-stable heterocyclic building block featuring a bromine substituent at the para position of the benzene ring. This electron-deficient aryl halide integrates readily into palladium-catalyzed cross-coupling reactions, enabling efficient access to biaryl architectures in medicinal chemistry and materials science applications.

Application

4-Bromobenzofuran serves as a versatile building block in synthetic organic chemistry, enabling palladium-catalyzed cross-coupling reactions such as Suzuki-Miyaura and Stille couplings. Its bromine substituent provides high reactivity under standard conditions while maintaining bench stability and compatibility with diverse functional groups. This compound functions effectively in the construction of biaryl systems and complex heterocyclic scaffolds relevant to medicinal chemistry and materials science.

Synthesis

  • Route1
    • 1-Bromo-3-(2,2-diethoxyethoxy)benzene|CS-1143544
      204452-94-8
    • ~40%
    • In-stock
      6-Bromobenzofuran|CS-W005044
      128851-73-0
    • In-stock
      4-Bromobenzofuran|CS-0054114
      128868-60-0

    References

    • Phytochemistry, , vol. 96, p. 132 - 147
  • Route2
    • null|null
      591-20-8
    • ~%
    • In-stock
      4-Bromobenzofuran|CS-0054114
      128868-60-0

    References

    • Journal of Medicinal Chemistry, , vol. 40, # 3 p. 322 - 330
  • Route3
    • null|null
      95-56-7
    • ~%
    • In-stock
      4-Bromobenzofuran|CS-0054114
      128868-60-0
    • In-stock
      7-Bromobenzofuran|CS-W019960
      133720-60-2

    References

    • EP1204654 B1, ; EP 1204654 B1

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

Quality Control

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Computational Chemistry Data

  • TPSA   13.14
  • LogP   3.1953
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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