2-(2,3,4-Trifluorophenyl)acetic acid

Name: 2-(2,3,4-Trifluorophenyl)acetic acid
Brand: ChemScene
Availability: InStock
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CAS No. 243666-12-8
Cat. No. CS-0052309
Purity≥98%
MDL No.MFCD00061235

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-(2,3,4-Trifluorophenyl)acetic acid|CS-0052309

Structure of 243666-12-8

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General Information

CAS No. 243666-12-8
Cat. No. CS-0052309
Purity ≥98%
MDL No. MFCD00061235
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₅F₃O₂
Molecular Weight 190.12
Synonym(s) 2,3,4-Trifluorophenylacetic acid
SMILES OC(=O)CC1=CC=C(F)C(F)=C1F

Description

This trifluorophenylacetic acid derivative features a sterically hindered, electron-deficient aryl group that enhances metabolic stability and lipophilicity. It serves as a key building block in medicinal chemistry for constructing bioactive scaffolds, particularly in kinase inhibitors and CNS-targeted compounds, where its fluorinated ring system improves membrane permeability and binding affinity.

Application

2-(2,3,4-Trifluorophenyl)acetic acid serves as a versatile building block for medicinal chemistry and agrochemical synthesis, enabling efficient incorporation of a trifluorinated aryl moiety into target molecules. Its carboxylic acid functionality facilitates direct coupling reactions, while the electron-deficient aromatic ring enhances metabolic stability and modulates lipophilicity. The compound exhibits excellent bench stability and compatibility with standard purification techniques, making it well-suited for high-throughput screening campaigns and process-scale applications.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

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Computational Chemistry Data

TPSA 37.3
LogP 1.731
H_Acceptors 1
H_Donors 1
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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2-(2,3,4-Trifluorophenyl)acetic acid

CAS No. 243666-12-8

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