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CS-W001157 4
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2-(2,3,4-Trifluorophenyl)acetonitrile

  • CAS No. 243666-13-9

  • Cat. No. CS-0157192
  • Purity≥95%
  • MDL No.MFCD00061234

*For research and further manufacturing use only, not for direct human use.

2-(2,3,4-Trifluorophenyl)acetonitrile|CS-0157192

Structure of 243666-13-9

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General Information

  • CAS No. 243666-13-9
  • Cat. No. CS-0157192
  • Purity ≥95%
  • MDL No. MFCD00061234
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₄F₃N
  • Molecular Weight 171.12
  • Synonym(s) 2,3,4-Trifluorophenylacetonitrile
  • SMILES C1=CC(=C(C(=C1CC#N)F)F)F

Description

2-(2,3,4-Trifluorophenyl)acetonitrile features a trifluorinated phenyl ring coupled to a nitrile-bearing acetyl side chain, delivering enhanced electron-withdrawing character and improved metabolic stability. This combination enables efficient integration into pharmaceutical scaffolds and synthetic intermediates requiring high functional group tolerance and structural rigidity under standard conditions.

Application

2-(2,3,4-Trifluorophenyl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive heterocycles and functionalized aryl derivatives. Its trifluorophenyl moiety enhances metabolic stability and modulates lipophilicity, while the nitrile group offers reliable reactivity in nucleophilic additions, reductions, and cyclizations. The compound exhibits excellent bench stability and compatibility with standard synthetic protocols, facilitating straightforward purification and integration into multi-step sequences.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   23.79
  • LogP   2.16998
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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