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CS-W001157 4
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3-Boc-aminopyrrolidine

  • CAS No. 99724-19-3

  • Cat. No. CS-D0663
  • Purity≥97%
  • MDL No.MFCD00059040

*For research and further manufacturing use only, not for direct human use.

3-Boc-aminopyrrolidine|CS-D0663

Structure of 99724-19-3

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General Information

  • CAS No. 99724-19-3
  • Cat. No. CS-D0663
  • Purity ≥97%
  • MDL No. MFCD00059040
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₈N₂O₂
  • Molecular Weight 186.25
  • Synonym(s) 3-(tert-Butoxycarbonylamino)pyrrolidine
  • SMILES O=C(OC(C)(C)C)NC1CCNC1

Description

3-Boc-aminopyrrolidine features a protected amine group enabling stable incorporation into complex molecular architectures. This bench-stable, moisture-tolerant building block integrates readily into peptide and small-molecule syntheses, offering reliable access to nitrogen-containing heterocycles under standard conditions.

Application

3-Boc-aminopyrrolidine serves as a versatile building block in medicinal chemistry, enabling efficient access to pyrrolidine-containing scaffolds via mild Boc deprotection. Its stability under standard reaction conditions and compatibility with diverse coupling and functionalization protocols make it ideal for constructing bioactive molecules, including kinase inhibitors and CNS-targeted compounds.

Synthesis

  • Route1

    References

    • KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY; CRYSTALGENOMICS, INC. Patent: WO2007/52938 A1, 2007 ; Location in patent: Page/Page column 23 ; WO 2007/052938 A1
  • Route2

    References

    • EP1460061 A1, ; Page 5-6 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07,GHS09
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335-H401-H411
Precautionary Statements : P261-P264-P271-P273-P280-P302+P352-P305+P351+P338-P362-P391-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   50.36
  • LogP   0.873
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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