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CS-W001157 4
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1-Methanesulfonylpiperidine-4-carboxylic acid

  • CAS No. 280772-00-1

  • Cat. No. CS-0046828
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1-Methanesulfonylpiperidine-4-carboxylic acid|CS-0046828

Structure of 280772-00-1

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General Information

  • CAS No. 280772-00-1
  • Cat. No. CS-0046828
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₃NO₄S
  • Molecular Weight 207.25
  • Synonym(s) 1-(Methylsulfonyl)piperidine-4-carboxylic acid
  • SMILES O=S(N1CCC(C(O)=O)CC1)(C)=O

Description

1-Methanesulfonylpiperidine-4-carboxylic acid features a rigid piperidine core functionalized with both a methanesulfonyl group and a carboxylic acid, enabling dual reactivity. This combination supports efficient conjugation in medicinal chemistry scaffolds and facilitates solubility modulation in peptide derivatization workflows.

Application

1-Methanesulfonylpiperidine-4-carboxylic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive heterocycles through standard coupling and functional group manipulation. The methanesulfonyl group enhances solubility and metabolic stability, while the carboxylic acid facilitates amide bond formation and conjugation. Its bench-stable nature and compatibility with common reaction conditions make it suitable for scalable, reproducible workflows in API development.

Synthesis

  • Route1
    • null|null
      847495-08-3
    • ~71%
    • In-stock
      1-Methanesulfonylpiperidine-4-carboxylic acid|CS-0046828
      280772-00-1

    References

    • CEPHALON, INC.; SEDE SECONDARIA DELLA CELL THERAPEUTICS, INC. Patent: WO2005/21558 A2, 2005 ; Location in patent: Page/Page column 227 ;
  • Route2
    • Ethyl 1-(methylsulfonyl)piperidine-4-carboxylate|CS-0299076
      217487-18-8
    • ~98%
    • In-stock
      1-Methanesulfonylpiperidine-4-carboxylic acid|CS-0046828
      280772-00-1

    References

    • Takeda Chemical Industries, Ltd. Patent: EP1359145 A1, 2003 ; Location in patent: Page/Page column 31 ;
  • Route3

    References

    • Imamura, Shinichi; Nishikawa, Youichi; Ichikawa, Takashi; Hattori, Taeko; Matsushita, Yoshihiro; Hashiguchi, Shohei; Kanzaki, Naoyuki; Iizawa, Yuji; Baba, Masanori; Sugihara, Yoshihiro Bioorganic and Medicinal Chemistry, 2005 , vol. 13, # 2 p. 397 - 416

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   74.68
  • LogP   -0.2574
  • H_Acceptors   3
  • H_Donors   1
  • Rotatable_Bonds   2

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