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CS-W001157 4
Total: USD 88.00

2,4,5-Trifluorophenylacetic acid

  • CAS No. 209995-38-0

  • Cat. No. CS-W015911
  • Purity≥98%
  • MDL No.MFCD00082479

*For research and further manufacturing use only, not for direct human use.

2,4,5-Trifluorophenylacetic acid|CS-W015911

Structure of 209995-38-0

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General Information

  • CAS No. 209995-38-0
  • Cat. No. CS-W015911
  • Purity ≥98%
  • MDL No. MFCD00082479
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₅F₃O₂
  • Molecular Weight 190.12
  • Synonym(s) Benzeneacetic acid, 2,4,5-trifluoro-
  • SMILES C1=C(C(=CC(=C1F)F)F)CC(O)=O

Application

2,4,5-Trifluorophenylacetic acid serves as a versatile building block in medicinal chemistry, enabling the synthesis of bioactive compounds through standard coupling reactions. Its trifluorinated aryl core enhances metabolic stability and modulates lipophilicity, while the carboxylic acid group facilitates direct derivatization or incorporation into peptide-like scaffolds. The compound exhibits good bench stability and is readily purified by crystallization, supporting its use in both research and process-scale applications.

Synthesis

  • Route1
    • null|null
      1036273-14-9
    • ~82%
    • In-stock
      2,4,5-Trifluorophenylacetic acid|CS-W015911
      209995-38-0

    References

    • F.I.S. FABBRICA ITALIANA SINTETICI S.P.A. Patent: WO2008/78350 A2, 2008 ; Location in patent: Page/Page column 18-19 ;
  • Route2
    • null|null
      680993-47-9
    • ~%
    • In-stock
      2,4,5-Trifluorophenylacetic acid|CS-W015911
      209995-38-0

    References

    • US2004/77901 A1, ; Page 3 ;
  • Route3
    • null|null
      367-23-7
    • ~%
    • In-stock
      2,4,5-Trifluorophenylacetic acid|CS-W015911
      209995-38-0

    References

    • US2014/58126 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS05,GHS07
Signal Word : Danger
UN#: 1759
Class : 8
Packing Group : Ⅲ
Hazard Statements : H315-H318-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   37.3
  • LogP   1.731
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   2

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