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CS-W001157 4
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(S)-Piperidin-3-ol

  • CAS No. 24211-55-0

  • Cat. No. CS-0029964
  • Purity≥95%
  • MDL No.MFCD08669819

*For research and further manufacturing use only, not for direct human use.

(S)-Piperidin-3-ol|CS-0029964

Structure of 24211-55-0

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General Information

  • CAS No. 24211-55-0
  • Cat. No. CS-0029964
  • Purity ≥95%
  • MDL No. MFCD08669819
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₁NO
  • Molecular Weight 101.15
  • Synonym(s) (3S)-3-Piperidinol; (S)-3-Hydroxypiperidine; (3S)-piperidin-3-ol
  • SMILES O[C@@H]1CNCCC1

Description

(S)-Piperidin-3-ol is a chiral building block featuring a hydroxyl group at the 3-position of the piperidine ring. This configuration imparts distinct stereochemical control in asymmetric synthesis, enabling precise construction of bioactive molecules. The compound exhibits favorable solubility and stability under standard conditions, facilitating integration into diverse synthetic pathways.

Application

(S)-Piperidin-3-ol serves as a key chiral building block in medicinal chemistry, enabling the construction of bioactive heterocycles through established functional group transformations. Its well-defined stereochemistry and bench-stable nature facilitate reliable incorporation into complex molecules, particularly in the synthesis of piperidine-based pharmaceutical scaffolds. The hydroxyl group provides a versatile handle for derivatization, including protection, oxidation, or coupling reactions, supporting broad synthetic utility in both academic and industrial R&D workflows.

Synthesis

  • Route1

    References

    • Olsen, Richard K.; Bhat, Krishna L.; Wardle, Robert B.; Hennen, William J.; Kini, Ganesh D. Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 896 - 899
  • Route2
    • null|null
      1451214-38-2
    • ~68%
    • In-stock
      (S)-Piperidin-3-ol|CS-0029964
      24211-55-0

    References

    • Higashiyama, Kimio; Matsumura, Masataka; Kurita, Emiko; Yamauchi, Takayasu Heterocycles, 2012 , vol. 86, # 1 p. 371 - 380
  • Route3

    References

    • Olsen, Richard K.; Bhat, Krishna L.; Wardle, Robert B.; Hennen, William J.; Kini, Ganesh D. Journal of Organic Chemistry, 1985 , vol. 50, # 6 p. 896 - 899

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   32.26
  • LogP   -0.2693
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   0

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