Benzyl 4-(aminomethyl)piperidine-1-carboxylate

Name: Benzyl 4-(aminomethyl)piperidine-1-carboxylate
Brand: ChemScene
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CAS No. 157023-34-2
Cat. No. CS-W002981
Purity≥98%
MDL No.MFCD03001690

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Benzyl 4-(aminomethyl)piperidine-1-carboxylate|CS-W002981

Structure of 157023-34-2

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General Information

CAS No. 157023-34-2
Cat. No. CS-W002981
Purity ≥98%
MDL No. MFCD03001690
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₄H₂₀N₂O₂
Molecular Weight 248.33
Synonym(s) None
SMILES O=C(OCC=1C=CC=CC1)N2CCC(CN)CC2

Description

Benzyl 4-(aminomethyl)piperidine-1-carboxylate features a piperidine core bearing a primary amine and benzyl ester functionality, enabling direct incorporation into bioactive molecule scaffolds. This bifunctional handle supports efficient derivatization in medicinal chemistry campaigns, particularly for targeting GPCRs and CNS-directed therapeutics. The compound exhibits favorable solubility and stability under standard handling conditions.

Application

Benzyl 4-(aminomethyl)piperidine-1-carboxylate serves as a versatile building block in medicinal chemistry, enabling efficient access to piperidine-based scaffolds. The benzyl ester group provides stability and facilitates straightforward deprotection under standard hydrogenolysis conditions. The pendant primary amine offers direct functionalization potential for conjugation or derivatization, supporting diverse synthetic routes in API development.

Synthesis

Route1
- 396072-76-7
- ~98%
- In-stock
  
  157023-34-2
References
- Yoneda, Yoshiyuki; Mimura, Tetuya; Kawagoe, Keiichi; Yasukouchi, Takanori; Tatematu, Toshiaki; Ito, Masayuki; Saito, Masaki; Sugimura, Masunobu; Kito, Fusako; Kawajiri, Shinichi Bioorganic and medicinal chemistry, 2002 , vol. 10, # 5 p. 1347 - 1359
Route2
- In-stock
  
  13139-17-8
- In-stock
  
  7144-05-0
- ~%
- In-stock
  
  157023-34-2
References
- US2003/119811 A1, ; US 20030119811 A1
Route3
- In-stock
  
  31139-36-3
- In-stock
  
  7144-05-0
- ~%
- In-stock
  
  157023-34-2
References
- US6329380 B1, ; US 6329380 B1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 55.56
LogP 1.9939
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 3

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Benzyl 4-(aminomethyl)piperidine-1-carboxylate

CAS No. 157023-34-2

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