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CS-W001157 4
Total: USD 88.00

(1-Methylpiperidin-4-yl)methanamine

  • CAS No. 7149-42-0

  • Cat. No. CS-W016551
  • Purity≥97%
  • MDL No.MFCD05022430

*For research and further manufacturing use only, not for direct human use.

(1-Methylpiperidin-4-yl)methanamine|CS-W016551

Structure of 7149-42-0

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General Information

  • CAS No. 7149-42-0
  • Cat. No. CS-W016551
  • Purity ≥97%
  • MDL No. MFCD05022430
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₁₆N₂
  • Molecular Weight 128.22
  • Synonym(s) 1-methylpiperidine-4-methylamine
  • SMILES C(N)C1CCN(CC1)C

Description

This primary amine features a flexible, electron-rich piperidine ring with a methylated nitrogen, enhancing solubility and basicity. It integrates readily into bioactive molecules, serving as a key scaffold in medicinal chemistry for targeted ligand design and synthetic intermediates.

Application

(1-Methylpiperidin-4-yl)methanamine serves as a versatile bifunctional building block in medicinal chemistry, enabling efficient access to nitrogen-containing scaffolds. Its primary amine functionality facilitates conjugation and derivatization, while the tertiary amine moiety enhances solubility and modulates basicity. The molecule exhibits good bench stability and compatibility with standard coupling reactions, supporting its use in peptide-like architectures and targeted library synthesis.

Synthesis

  • Route1

    References

    • Sun, Li; Liang, Chris; Shirazian, Sheri; Zhou, Yong; Miller, Todd; Cui, Jean; Fukuda, Juri Y.; Chu, Ji-Yu; Nematalla, Asaad; Wang, Xueyan; Chen, Hui; Sistla, Anand; Luu, Tony C.; Tang, Flora; Wei, James; Tang, Cho Journal of Medicinal Chemistry, 2003 , vol. 46, # 7 p. 1116 - 1119
  • Route2

    References

    • Journal of Medicinal Chemistry, , vol. 46, # 7 p. 1116 - 1119
  • Route3

    References

    • Yakugaku Zasshi, , vol. 76, p. 968 Chem.Abstr., , p. 2771

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02,GHS05,GHS07
Signal Word : Danger
UN#: 2733
Class : 3 (8)
Packing Group : Ⅲ
Hazard Statements : H226-H302-H314
Precautionary Statements : P210-P233-P240-P241-P242-P243-P260-P264-P270-P280-P301+P330+P331-P304+P340-P330-P363-P370+P378-P405-P501

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Computational Chemistry Data

  • TPSA   29.26
  • LogP   0.2869
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   1

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