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CS-W001157 4
Total: USD 88.00

2,2-Difluoro-cyclopropaneboronic acid pinacol ester

  • CAS No. 2411405-92-8

  • Cat. No. CS-0342822
  • Purity≥97%
  • MDL No.MFCD32642521

*For research and further manufacturing use only, not for direct human use.

2,2-Difluoro-cyclopropaneboronic acid pinacol ester|CS-0342822

Structure of 2411405-92-8

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General Information

  • CAS No. 2411405-92-8
  • Cat. No. CS-0342822
  • Purity ≥97%
  • MDL No. MFCD32642521
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₁₅BF₂O₂
  • Molecular Weight 204.02
  • Synonym(s) None
  • SMILES FC1(F)CC1B2OC(C)(C)C(O2)(C)C

Description

This difluorocyclopropaneboronic ester features a strained cyclopropyl ring bearing two fluorine atoms and a boronate functionality, enabling direct incorporation into cross-coupling reactions. The pinacol protection enhances stability and solubility in organic media, facilitating handling and integration into synthetic sequences.

Application

2,2-Difluoro-cyclopropaneboronic acid pinacol ester serves as a stable, bench-ready building block for the incorporation of fluorinated cyclopropane motifs into complex molecular architectures. Its robust pinacol boronate ester functionality enables reliable Suzuki-Miyaura cross-coupling reactions under standard conditions, offering high functional group tolerance and predictable stereochemical transfer. This reagent facilitates efficient access to fluorinated heterocycles and medicinal chemistry scaffolds, particularly in applications requiring metabolic stability and conformational rigidity.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   18.46
  • LogP   2.4878
  • H_Acceptors   2
  • H_Donors   0
  • Rotatable_Bonds   1

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