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CS-W001157 4
Total: USD 88.00

Fmoc-Phe(CF2PO3)-OH

  • CAS No. 160751-44-0

  • Cat. No. CS-0201618
  • Molecule weight517.42
  • Purity≥98%
  • MDL No.MFCD01317828

*For research and further manufacturing use only, not for direct human use.

Fmoc-Phe(CF2PO3)-OH|CS-0201618

Structure of 160751-44-0

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General Information

  • CAS No. 160751-44-0
  • Cat. No. CS-0201618
  • Purity ≥98%
  • MDL No. MFCD01317828
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₂F₂NO₇P
  • Molecular Weight 517.42
  • Synonym(s) None
  • SMILES OC(=O)[C@H](CC1=CC=C(C=C1)C(F)(F)P(O)(O)=O)NC(=O)OCC2C3=C(C=CC=C3)C4=C2C=CC=C4

Description

Fmoc-Phe(CF2PO3)-OH features a trifluoromethylphosphonate-modified phenylalanine residue, offering enhanced metabolic stability and resistance to enzymatic degradation. This derivative integrates readily into peptide chains under standard coupling conditions, delivering robust performance in solid-phase synthesis workflows.

Synthesis

  • Route1
    • (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-((diethoxyphosphoryl)difluoromethyl)phenyl)propanoic acid|CS-0725227
      156017-45-7
    • ~%
    • In-stock
      Fmoc-Phe(CF2PO3)-OH|CS-0201618
      160751-44-0

    References

    • Solas, Dennis; Hale, Ron L.; Patel, Dinesh V. Journal of Organic Chemistry, 1996 , vol. 61, # 4 p. 1537 - 1539
  • Route2

    References

    • Solas, Dennis; Hale, Ron L.; Patel, Dinesh V. Journal of Organic Chemistry, 1996 , vol. 61, # 4 p. 1537 - 1539
  • Route3
    • null|null
      876-07-3
    • ~%
    • In-stock
      Fmoc-Phe(CF2PO3)-OH|CS-0201618
      160751-44-0

    References

    • Solas, Dennis; Hale, Ron L.; Patel, Dinesh V. Journal of Organic Chemistry, 1996 , vol. 61, # 4 p. 1537 - 1539

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   133.16
  • LogP   4.448
  • H_Acceptors   4
  • H_Donors   4
  • Rotatable_Bonds   8

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