Fmoc-D-Phe(4-CF3)-OH

Name: Fmoc-D-Phe(4-CF3)-OH
Brand: ChemScene
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CAS No. 238742-88-6
Cat. No. CS-W013839
Purity≥97%
MDL No.MFCD00797582

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

An item is classified as a dangerous good if our website displays Hazardous Material (HazMat) information for it.

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General Information

CAS No. 238742-88-6
Cat. No. CS-W013839
Purity ≥97%
MDL No. MFCD00797582
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₀F₃NO₄
Molecular Weight 455.43
Synonym(s) None
SMILES O=C(O)[C@@H](CC1=CC=C(C(F)(F)F)C=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-D-Phe(4-CF3)-OH features a fluorinated para-trifluoromethyl phenylalanine residue, enhancing metabolic stability and lipophilicity. This derivative integrates efficiently into peptide chains via standard coupling protocols, offering improved membrane permeability and resistance to enzymatic degradation in bioactive sequence design.

Application

Fmoc-D-Phe(4-CF₃)-OH serves as a valuable building block in peptide synthesis, offering enhanced lipophilicity and metabolic stability due to the electron-withdrawing trifluoromethyl group at the para position. Its D-configured phenylalanine moiety facilitates incorporation into bioactive peptides where resistance to proteolytic degradation is required. The Fmoc group enables efficient orthogonal protection for solid-phase synthesis, while the side chain's stability simplifies purification and handling under standard bench conditions.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

Quality Control

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Computational Chemistry Data

TPSA 75.63
LogP 5.2398
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Life Science Amino Acids and their Derivatives Phenylalanine and derivatives

Building Blocks Functional Group Fmoc

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

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Fmoc-D-Phe(4-CF3)-OH

CAS No. 238742-88-6

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