Fmoc-N-Me-L-Met-OH

Name: Fmoc-N-Me-L-Met-OH
Brand: ChemScene
Availability: InStock
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CAS No. 84000-12-4
Cat. No. CS-0086979
Purity≥98%
MDL No.MFCD18782827

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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Structure of 84000-12-4

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General Information

CAS No. 84000-12-4
Cat. No. CS-0086979
Purity ≥98%
MDL No. MFCD18782827
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₁H₂₃NO₄S
Molecular Weight 385.48
Synonym(s) N-Methyl methionine
SMILES CSCC[C@@H](C(O)=O)N(C(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O)C

Description

Fmoc-N-Me-L-Met-OH is a protected methionine derivative featuring a fluorenylmethoxy carbonyl group and a methylated nitrogen, enabling efficient incorporation into peptide chains. The N-methyl substitution enhances resistance to enzymatic degradation while maintaining compatibility with standard solid-phase synthesis protocols. This analog supports the synthesis of bioactive peptides requiring stable, hydrophobic side chains.

Synthesis

Route1
- 84000-02-2
- ~21%
- In-stock
  
  84000-12-4
References
- Freidinger, Roger M.; Hinkle, Jeffery S.; Perlow, Debra S.; Arison, Byron H. Journal of Organic Chemistry, 1983 , vol. 48, # 1 p. 77 - 81
Route2
- In-stock
  
  71989-28-1
- ~%
- In-stock
  
  84000-12-4
References
- Journal of Organic Chemistry, , vol. 48, # 1 p. 77 - 81

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 66.84
LogP 4.0736
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 7

Other Classifications

Life Science Amino Acids and their Derivatives Methionine and derivatives

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Thioether

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-N-Me-L-Met-OH

CAS No. 84000-12-4

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