2-Amino-6-chloroimidazo[1,2-b]pyridazine

Name: 2-Amino-6-chloroimidazo[1,2-b]pyridazine
Brand: ChemScene
Availability: InStock
Rating: 5 (1 reviews)

CAS No. 887625-09-4
Cat. No. CS-0044497
Purity≥96%
MDL No.MFCD16495902

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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2-Amino-6-chloroimidazo[1,2-b]pyridazine|CS-0044497

Structure of 887625-09-4

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General Information

CAS No. 887625-09-4
Cat. No. CS-0044497
Purity ≥96%
MDL No. MFCD16495902
Storage 4°C, protect from light, stored under nitrogen
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₅ClN₄
Molecular Weight 168.58
Synonym(s) 6-Chloroimidazo[1,2-b]pyridazin-2-amine
SMILES NC1=CN2N=C(Cl)C=CC2=N1

Description

2-Amino-6-chloroimidazo[1,2-b]pyridazine is a heterocyclic scaffold featuring a chlorine atom at the 6-position and an amino group at the 2-position, offering enhanced reactivity for downstream functionalization. This electron-deficient imidazopyridazine core enables efficient coupling in medicinal chemistry applications, particularly in kinase inhibitor development. The compound exhibits bench-stable handling characteristics and compatibility with standard synthetic protocols.

Application

2-Amino-6-chloroimidazo[1,2-b]pyridazine serves as a versatile heterocyclic building block in medicinal chemistry, enabling the construction of imidazo[1,2-b]pyridazine scaffolds through palladium-catalyzed cross-coupling reactions. The amino group facilitates further derivatization via acylation or alkylation, while the chloro substituent provides a reliable handle for nucleophilic substitution. Its bench-stable nature and compatibility with standard reaction conditions make it well-suited for modular synthesis workflows in API development.

Synthesis

Route1
- In-stock
  
  947248-50-2
- ~90%
- In-stock
  
  887625-09-4
References
- US2009/163489 A1, ; Page/Page column 20 ; US 20090163489 A1
Route2
- 1162680-83-2
- ~41%
- In-stock
  
  887625-09-4
References
- US2009/163489 A1, ; Page/Page column 19 ; US 20090163489 A1

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

TPSA 56.21
LogP 0.9649
H_Acceptors 4
H_Donors 1
Rotatable_Bonds 0

Other Classifications

Building Blocks Functional Group Chloride

Building Blocks Skeleton Aromatic heterocycle compounds Imidazole compounds

Building Blocks Skeleton Aromatic heterocycle compounds Pyridazine compounds

Key Words

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2-Amino-6-chloroimidazo[1,2-b]pyridazine

CAS No. 887625-09-4

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