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CS-W001157 4
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Methyl 3-methoxypyridine-2-carboxylate

  • CAS No. 24059-83-4

  • Cat. No. CS-W022834
  • Purity≥97%
  • MDL No.MFCD06412569

*For research and further manufacturing use only, not for direct human use.

Methyl 3-methoxypyridine-2-carboxylate|CS-W022834

Structure of 24059-83-4

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General Information

  • CAS No. 24059-83-4
  • Cat. No. CS-W022834
  • Purity ≥97%
  • MDL No. MFCD06412569
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₈H₉NO₃
  • Molecular Weight 167.16
  • Synonym(s) 3-Methoxypyridine-2-carboxylicacidmethylester
  • SMILES COC1=CC=CN=C1C(=O)OC

Description

Methyl 3-methoxypyridine-2-carboxylate features a pyridine core functionalized with a methoxy group at the 3-position and a methyl ester at the 2-position. This electron-deficient heterocycle integrates readily into synthetic sequences requiring polar, bench-stable intermediates. The methoxy substituent enhances solubility and modulates reactivity in transition metal-catalyzed couplings.

Application

Methyl 3-methoxypyridine-2-carboxylate serves as a versatile pyridine-based building block for medicinal chemistry and catalytic synthesis. Its ortho-carboxylate functionality enables efficient derivatization via nucleophilic substitution, ester reduction, or transition-metal-catalyzed coupling reactions. The methoxy group provides moderate electronic modulation and enhances solubility in organic solvents, facilitating purification and handling during multi-step synthesis.

Synthesis

  • Route1
    • In-stock
      Methyl 3-hydroxypicolinate|CS-W022831
      62733-99-7
    • null|null
      74-88-4
    • ~55%
    • In-stock
      Methyl 3-methoxypyridine-2-carboxylate|CS-W022834
      24059-83-4

    References

    • RESVERLOGIX CORP.; JOHANSSON, Jan, O.; HANSEN, Henrik, C.; CHIACCHIA, Fabrizio, S.; WONG, Norman, C.W. Patent: WO2007/16525 A2, 2007 ; Location in patent: Page/Page column 50 ; WO 2007/016525 A2
  • Route2
    • In-stock
      3-Hydroxypicolinic acid, matrix substance for MALDI-MS|CS-0899663
      874-24-8
    • null|null
      74-88-4
    • ~%
    • In-stock
      Methyl 3-methoxypyridine-2-carboxylate|CS-W022834
      24059-83-4

    References

    • Bioorganic and Medicinal Chemistry Letters, , vol. 15, # 3 p. 635 - 638
  • Route3

    References

    • US2013/281396 A1, ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   48.42
  • LogP   0.8768
  • H_Acceptors   4
  • H_Donors   0
  • Rotatable_Bonds   2

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