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CS-W001157 4
Total: USD 88.00

2,3-Dichloropyridine

  • CAS No. 2402-77-9

  • Cat. No. CS-W013307
  • Purity≥97%
  • MDL No.MFCD00006229

*For research and further manufacturing use only, not for direct human use.

2,3-Dichloropyridine|CS-W013307

Structure of 2402-77-9

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General Information

  • CAS No. 2402-77-9
  • Cat. No. CS-W013307
  • Purity ≥97%
  • MDL No. MFCD00006229
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₃Cl₂N
  • Molecular Weight None
  • Synonym(s) None
  • SMILES C1=C(C(=NC=C1)Cl)Cl

Description

2,3-Dichloropyridine serves as a pivotal heterocyclic scaffold in medicinal chemistry and agrochemical synthesis. This electron-deficient pyridine derivative features two chlorine substituents at adjacent positions, enabling selective functionalization via cross-coupling or nucleophilic substitution. The molecule exhibits high stability under standard conditions and facilitates efficient incorporation into complex molecular architectures.

Application

2,3-Dichloropyridine serves as a versatile building block in medicinal chemistry and agrochemical synthesis, enabling regioselective functionalization via cross-coupling and nucleophilic substitution reactions. Its dichloro substitution pattern provides orthogonal reactivity for sequential derivatization, while the pyridine core offers favorable electronic properties for transition metal-catalyzed transformations. The compound exhibits good bench stability and is readily purified by distillation or chromatography, facilitating integration into multi-step synthetic sequences.

Synthesis

  • Route1

    References

    • E. I. DU PONT DE NEMOURS AND COMPANY Patent: WO2009/114589 A1, 2009 ; Location in patent: Page/Page column 13-14 ;
  • Route2
    • null|null
      462-08-8
    • ~%
    • In-stock
      2,3-Dichloropyridine|CS-W013307
      2402-77-9

    References

    • US2010/160641 A1, ; Page/Page column 4 ;
  • Route3
    • 2-Chloronicotinoyl chloride|CS-W017427
      49609-84-9
    • ~43%
    • In-stock
      2,3-Dichloropyridine|CS-W013307
      2402-77-9

    References

    • LONZA LTD; ZARAGOZA DOERWALD, Florencio Patent: WO2013/20938 A1, 2013 ; Location in patent: Page/Page column 17;18;19 ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   12.89
  • LogP   2.3884
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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