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CS-W001157 4
Total: USD 88.00

2-Methoxy-2-methylpropan-1-ol

  • CAS No. 22665-67-4

  • Cat. No. CS-0146594
  • Purity≥96%
  • MDL No.MFCD18253497

*For research and further manufacturing use only, not for direct human use.

2-Methoxy-2-methylpropan-1-ol|CS-0146594

Structure of 22665-67-4

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General Information

  • CAS No. 22665-67-4
  • Cat. No. CS-0146594
  • Purity ≥96%
  • MDL No. MFCD18253497
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₅H₁₂O₂
  • Molecular Weight 104.15
  • Synonym(s) 2-Methoxy-2-methyl-1-propanol
  • SMILES CC(C)(OC)CO

Description

2-Methoxy-2-methylpropan-1-ol is a tertiary alcohol featuring a methoxy-substituted methyl group and a hydroxyl-bearing primary carbon. This structure imparts enhanced solubility in polar solvents and improved stability under standard bench conditions. The molecule serves as a robust, moisture-tolerant building block in synthetic transformations requiring steric protection or controlled reactivity.

Application

2-Methoxy-2-methylpropan-1-ol serves as a stable, bench-friendly solvent and protecting group reagent in synthetic organic chemistry. Its tertiary alcohol functionality enables selective protection of aldehydes and ketones under mild conditions, while the methoxy group enhances solubility and stability. The molecule facilitates efficient glycosylation reactions and functions effectively in asymmetric synthesis workflows due to its low nucleophilicity and compatibility with diverse reaction conditions.

Synthesis

  • Route1
    • null|null
      558-30-5
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      67-56-1
    • ~89%
    • In-stock
      2-Methoxy-2-methylpropan-1-ol|CS-0146594
      22665-67-4

    References

    • DRAXIS Specialty Pharmaceuticals Inc. Patent: US2008/102028 A1, 2008 ; Location in patent: Page/Page column 9; 10 ;
  • Route2

    References

    • Takeuchi, Hiroshi; Kishioka, Hiroaki; Kitajima, Kunio Journal of Physical Organic Chemistry, 1995 , vol. 8, # 2 p. 121 - 126
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    References

    • Leggetter,B.E.; Brown,R.K. Canadian Journal of Chemistry, 1964 , vol. 42, p. 990 - 1004

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS02
Signal Word : Danger
UN#: 1993
Class : 3
Packing Group : Ⅲ
Hazard Statements : H225
Precautionary Statements : P210-P243-P273-P403

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   0.4037
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   2

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