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CS-W001157 4
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2-(Benzyloxy)-2-methylpropan-1-ol

  • CAS No. 91968-71-7

  • Cat. No. CS-0112724
  • Purity≥95%
  • MDL No.MFCD08459314

*For research and further manufacturing use only, not for direct human use.

2-(Benzyloxy)-2-methylpropan-1-ol|CS-0112724

Structure of 91968-71-7

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General Information

  • CAS No. 91968-71-7
  • Cat. No. CS-0112724
  • Purity ≥95%
  • MDL No. MFCD08459314
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₁H₁₆O₂
  • Molecular Weight 180.24
  • Synonym(s) 2-Benzyloxy-2-methylpropan-1-OL
  • SMILES CC(C)(CO)OCC1=CC=CC=C1

Description

This benzyloxy-substituted alcohol features a sterically hindered tertiary carbon center, enhancing stability and facilitating selective functionalization. The benzyloxy group imparts solubility in organic media and serves as a removable protecting group for diols and polyols under mild acidic conditions.

Application

2-(Benzyloxy)-2-methylpropan-1-ol serves as a stable, bench-ready allylic alcohol derivative that facilitates efficient etherification and protection strategies in complex molecule synthesis. Its tertiary alcohol functionality enables selective derivatization under mild conditions, while the benzyloxy group provides orthogonal protection compatibility. The molecule exhibits excellent stability and ease of purification, making it a reliable building block for pharmaceutical intermediates and natural product synthesis.

Synthesis

  • Route1
    • null|null
      347400-73-1
    • ~38%
    • In-stock
      2-(Benzyloxy)-2-methylpropan-1-ol|CS-0112724
      91968-71-7

    References

    • Jandeleit, Bernd; Li, Yunxiao; Gallop, Mark A.; Zerangue, Noa; Virsik, Peter A.; Fischer, Wolf-Nicolas Patent: US2009/82464 A1, 2009 ; Location in patent: Page/Page column 44 ;
  • Route2

    References

    • Canadian Journal of Chemistry, , vol. 42, p. 990 - 1004
  • Route3
    • null|null
      100-39-0
    • ~%
    • In-stock
      2-(Benzyloxy)-2-methylpropan-1-ol|CS-0112724
      91968-71-7

    References

    • Journal of Organic Chemistry, , vol. 63, # 6 p. 1885 - 1892

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362

Quality Control

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Computational Chemistry Data

  • TPSA   29.46
  • LogP   1.9741
  • H_Acceptors   2
  • H_Donors   1
  • Rotatable_Bonds   4

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