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CS-W001157 4
Total: USD 88.00

2-Methylpropane-1,2-diol

  • CAS No. 558-43-0

  • Cat. No. CS-W005057
  • Purity≥98%
  • MDL No.MFCD00971926

*For research and further manufacturing use only, not for direct human use.

2-Methylpropane-1,2-diol|CS-W005057

Structure of 558-43-0

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General Information

  • CAS No. 558-43-0
  • Cat. No. CS-W005057
  • Purity ≥98%
  • MDL No. MFCD00971926
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₁₀O₂
  • Molecular Weight 90.12
  • Synonym(s) Isobutene glycol
  • SMILES CC(O)(C)CO

Description

2-Methylpropane-1,2-diol is a branched-chain diol featuring adjacent hydroxyl groups on a tertiary carbon center. This structure imparts enhanced solubility in polar solvents and contributes to its stability under standard handling conditions. The molecule integrates readily into synthetic pathways requiring sterically hindered, hydrophilic intermediates.

Application

2-Methylpropane-1,2-diol serves as a stable, bench-ready diol scaffold for the synthesis of heterocycles and functionalized building blocks. Its tertiary hydroxyl group provides enhanced resistance to oxidation, while the adjacent primary alcohol enables selective derivatization. The molecule functions effectively in protection strategies and facilitates access to complex intermediates via standard coupling and cyclization protocols.

Synthesis

  • Route1

    References

    • ABBOTT LABORATORIES Patent: US2010/69348 A1, 2010 ; Location in patent: Page/Page column 50; 51 ;
  • Route2
    • null|null
      2110-78-3
    • ~65%
    • In-stock
      2-Methylpropane-1,2-diol|CS-W005057
      558-43-0

    References

    • ABBOTT LABORATORIES; FROST, Jennifer, M.; LATSHAW, Steven, P.; DART, Michael, J.; CARROLL, William, A.; PEREZ-MEDRANO, Arturo; KOLASA, Teodozyj; PATEL, Meena; NELSON, Derek, W.; LI, Tongmei; PEDDI, Sridhar; WANG, Xueqing; LUI, Bo Patent: WO2010/71783 A1, 2010 ; Location in patent: Page/Page column 75-76 ; WO 2010/071783 A1
  • Route3
    • null|null
      80-55-7
    • ~%
    • In-stock
      2-Methylpropane-1,2-diol|CS-W005057
      558-43-0

    References

    • US2137407 , ; US2094611 , ;

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   40.46
  • LogP   -0.2504
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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