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CS-W001157 4
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(1H-Imidazol-2-yl)methanamine dihydrochloride

  • CAS No. 22600-77-7

  • Cat. No. CS-0037877
  • Molecule weight170.04
  • Purity≥97%
  • MDL No.MFCD06738779

*For research and further manufacturing use only, not for direct human use.

(1H-Imidazol-2-yl)methanamine dihydrochloride|CS-0037877

Structure of 22600-77-7

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General Information

  • CAS No. 22600-77-7
  • Cat. No. CS-0037877
  • Purity ≥97%
  • MDL No. MFCD06738779
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₉Cl₂N₃
  • Molecular Weight 170.04
  • Synonym(s) C-(1H-IMIDAZOL-2-YL)-METHYLAMINE DIHYDROCHLORIDE
  • SMILES NCC1=NC=CN1.Cl.Cl

Description

(1H-Imidazol-2-yl)methanamine dihydrochloride features a reactive imidazole core paired with a primary amine handle, enabling direct conjugation in bioconjugation and medicinal chemistry. The dihydrochloride salt enhances solubility and stability under standard conditions, facilitating handling in aqueous workflows. This compound integrates readily into peptide and small-molecule scaffolds, offering a robust platform for targeted molecular design.

Application

(1H-Imidazol-2-yl)methanamine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to imidazole-containing scaffolds. Its dual protonation enhances solubility and stability in aqueous media, facilitating handling and purification. The primary amine functionality readily participates in nucleophilic substitution and reductive amination reactions, supporting diverse functionalization for API development.

Synthesis

  • Route1
    • null|null
      62457-77-6
    • ~68%
    • In-stock
      (1H-Imidazol-2-yl)methanamine dihydrochloride|CS-0037877
      22600-77-7

    References

    • Heterocycles, , vol. 57, # 12 p. 2393 - 2400
  • Route2
    • null|null
      92741-91-8
    • ~61%
    • In-stock
      (1H-Imidazol-2-yl)methanamine dihydrochloride|CS-0037877
      22600-77-7
    • In-stock
      Phthalic acid|CS-0009407
      88-99-3

    References

    • Journal of Heterocyclic Chemistry, , vol. 21, p. 753 - 757

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319-H335
Precautionary Statements : P261-P264-P271-P280-P302+P352-P304+P340-P362+P364-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   54.7
  • LogP   0.712
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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