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1H-Imidazole-2-carboxamide

  • CAS No. 16093-82-6

  • Cat. No. CS-0060699
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

1H-Imidazole-2-carboxamide|CS-0060699

Structure of 16093-82-6

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General Information

  • CAS No. 16093-82-6
  • Cat. No. CS-0060699
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₄H₅N₃O
  • Molecular Weight 111.10
  • Synonym(s) 1H-Imidazol-2-carboxamide
  • SMILES C1=CN=C(C(=O)N)N1

Description

1H-Imidazole-2-carboxamide features a polar, heterocyclic core with dual hydrogen-bonding capabilities, enabling robust interactions in supramolecular systems. This bench-stable scaffold integrates readily into bioactive molecules, serving as a key pharmacophore in kinase inhibitors and ligand design.

Application

1H-Imidazole-2-carboxamide serves as a versatile building block in medicinal chemistry, enabling the construction of bioactive heterocycles due to its dual hydrogen-bond donor/acceptor capacity and compatibility with standard coupling reactions. Its bench-stable nature and clean purification profile facilitate integration into multi-step syntheses, particularly for kinase inhibitors and antifungal agents where imidazole scaffolds are prevalent.

Synthesis

  • Route1
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      74840-92-9
    • ~86%
    • In-stock
      1H-Imidazole-2-carboxamide|CS-0060699
      16093-82-6

    References

    • Dirlam, John P.; James, Richard B.; Shoop, Eleanor V. Journal of Heterocyclic Chemistry, 1980 , vol. 17, p. 409 - 411

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   71.77
  • LogP   -0.4914
  • H_Acceptors   2
  • H_Donors   2
  • Rotatable_Bonds   1

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