1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine dihydrochloride

Name: 1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine dihydrochloride
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CAS No. 755039-78-2
Cat. No. CS-0130125
Purity≥95%
MDL No.MFCD09759192

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1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine dihydrochloride|CS-0130125

Structure of 755039-78-2

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General Information

CAS No. 755039-78-2
Cat. No. CS-0130125
Purity ≥95%
MDL No. MFCD09759192
Storage Store at room temperature, keep dry and cool
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₁₀H₂₂Cl₂N₂O
Molecular Weight 257.20
Synonym(s) 1-(Tetrahydro-2H-pyran-4-yl)-4-piperidinaMine dihydrochloride
SMILES NC1CCN(C2CCOCC2)CC1.[H]Cl.[H]Cl

Description

This dihydrochloride salt features a tetrahydropyran-4-yl-piperidinamine scaffold with enhanced solubility and stability under standard conditions. The piperidine nitrogen bears a protonated amine, while the tetrahydrotetrahydropyran ring imparts conformational rigidity and metabolic resistance. This combination enables efficient incorporation into bioactive molecules requiring polar, yet lipophilic, pharmacophores.

Application

1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine dihydrochloride serves as a versatile building block in medicinal chemistry, enabling efficient access to saturated nitrogen heterocycles. The tetrahydropyranyl group provides robust protection for hydroxyl functionalities during synthesis, while the piperidinamine core offers a readily functionalizable amine handle. Its stability under standard reaction conditions and ease of purification facilitate integration into multi-step syntheses of bioactive molecules and API intermediates.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330-P501

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Computational Chemistry Data

TPSA 38.49
LogP 1.4321
H_Acceptors 3
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Skeleton Aliphatic heterocycle compounds Tetrahydropyran compounds

Building Blocks Skeleton Aliphatic heterocycle compounds Piperidine compounds

Key Words

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1-(Tetrahydro-2H-pyran-4-yl)piperidin-4-amine dihydrochloride

CAS No. 755039-78-2

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