Tel:

Email:

EN
Cat. No. Size / Unit Price Qty
CS-W001157 4
Total: USD 88.00

Thalidomide-Piperazine 5-fluoride

  • CAS No. 2222114-22-7

  • Cat. No. CS-0168629
  • Purity≥95%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Thalidomide-Piperazine 5-fluoride|CS-0168629

Structure of 2222114-22-7

Please choose your location and provide accurate information for you
Size Stock
Price Quantity

* Please select Quantity before adding items.

General Information

  • CAS No. 2222114-22-7
  • Cat. No. CS-0168629
  • Purity ≥95%
  • MDL No. None
  • Storage 4°C, protect from light
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₇H₁₇FN₄O₄
  • Molecular Weight 360.34
  • Synonym(s) None
  • SMILES O=C1N(C(CC2)C(NC2=O)=O)C(C3=C1C=C(N4CCNCC4)C(F)=C3)=O

Description

Thalidomide-Piperazine 5-fluoride integrates a piperazine-modified thalidomide core with a 5-fluoride substituent, enhancing solubility and metabolic stability. This derivative exhibits improved pharmacokinetic properties while retaining the immunomodulatory profile of parent thalidomide, enabling precise targeting in oncology and autoimmune disease research.

Application

Thalidomide-Piperazine 5-fluoride serves as a synthetically versatile scaffold for medicinal chemistry exploration, combining the established pharmacophore of thalidomide with a piperazine linker and electron-withdrawing 5-fluoride substitution. The fluorinated variant enhances metabolic stability and modulates electronic properties, enabling predictable reactivity in amide couplings and nucleophilic substitutions. Its bench-stable crystalline form facilitates handling and purification, supporting iterative optimization in target-directed synthesis.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

Quality Control

To search for quality control of cas , please enter both the product number and the lot/batch number.

Computational Chemistry Data

  • TPSA   98.82
  • LogP   -0.2643
  • H_Acceptors   8
  • H_Donors   2
  • Rotatable_Bonds   2

Other Classifications

Recently Viewed Products

Leave US a Message
Upload Pictures

Key Words

  • Thalidomide-Piperazine 5-fluoride sigmaThalidomide-Piperazine 5-fluoride manufacturerThalidomide-Piperazine 5-fluoride priceThalidomide-Piperazine 5-fluoride structureThalidomide-Piperazine 5-fluoride SDSbuy Thalidomide-Piperazine 5-fluorideThalidomide-Piperazine 5-fluoride supplierThalidomide-Piperazine 5-fluoride usesThalidomide-Piperazine 5-fluoride molecular weightprice of Thalidomide-Piperazine 5-fluorideThalidomide-Piperazine 5-fluoride chemical name formula of Thalidomide-Piperazine 5-fluoride
This product is not sold in the region.
Confirm
How to get a Lot Number

Lot numbers can be found on the outside label of a product:

ChemScene Label