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CS-W001157 4
Total: USD 88.00

Thalidomide-piperazine-Boc

  • CAS No. 2222114-64-7

  • Cat. No. CS-0168628
  • Molecule weight442.47
  • Purity≥98%
  • MDL No.MFCD32705088

*For research and further manufacturing use only, not for direct human use.

Thalidomide-piperazine-Boc|CS-0168628

Structure of 2222114-64-7

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General Information

  • CAS No. 2222114-64-7
  • Cat. No. CS-0168628
  • Purity ≥98%
  • MDL No. MFCD32705088
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₂H₂₆N₄O₆
  • Molecular Weight 442.47
  • Synonym(s) None
  • SMILES O=C(N1CCN(C2=CC3=C(C(N(C(CC4)C(NC4=O)=O)C3=O)=O)C=C2)CC1)OC(C)(C)C

Description

Thalidomide-piperazine-Boc integrates the thalidomide scaffold with a piperazine linker and Boc protection, enabling stable incorporation into peptide conjugates. This derivative facilitates targeted delivery in medicinal chemistry campaigns, offering enhanced solubility and controlled release properties under standard conditions.

Application

Thalidomide-piperazine-Boc serves as a key intermediate in the synthesis of thalidomide analogs, leveraging the piperazine moiety for enhanced solubility and functionalization versatility. The Boc group provides stability during storage and facilitates straightforward deprotection under mild acidic conditions. This compound enables efficient access to targeted scaffolds in medicinal chemistry campaigns focused on immunomodulatory and anti-angiogenic agents.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS06,GHS08
Signal Word : Danger
UN#: 2811
Class : 6.1
Packing Group : Ⅲ
Hazard Statements : H301-H312-H361
Precautionary Statements : P264-P270-P280-P302+P352-P330-P362+P364-P405-P501

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Computational Chemistry Data

  • TPSA   116.33
  • LogP   1.2939
  • H_Acceptors   10
  • H_Donors   1
  • Rotatable_Bonds   2

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