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Structure of 2222114-22-7
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Thalidomide-Piperazine 5-fluoride integrates a piperazine-modified thalidomide core with a 5-fluoride substituent, enhancing solubility and metabolic stability. This derivative exhibits improved pharmacokinetic properties while retaining the immunomodulatory profile of parent thalidomide, enabling precise targeting in oncology and autoimmune disease research.
Thalidomide-Piperazine 5-fluoride serves as a synthetically versatile scaffold for medicinal chemistry exploration, combining the established pharmacophore of thalidomide with a piperazine linker and electron-withdrawing 5-fluoride substitution. The fluorinated variant enhances metabolic stability and modulates electronic properties, enabling predictable reactivity in amide couplings and nucleophilic substitutions. Its bench-stable crystalline form facilitates handling and purification, supporting iterative optimization in target-directed synthesis.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H315-H319
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Precautionary Statements : P264-P280-P302+P352-P362+P364
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Lot numbers can be found on the outside label of a product: