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CS-W001157 4
Total: USD 88.00

6-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one

  • CAS No. 22123-19-9

  • Cat. No. CS-0153238
  • Purity≥98%
  • MDL No.MFCD00042479

*For research and further manufacturing use only, not for direct human use.

6-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one|CS-0153238

Structure of 22123-19-9

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General Information

  • CAS No. 22123-19-9
  • Cat. No. CS-0153238
  • Purity ≥98%
  • MDL No. MFCD00042479
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₆F₃NO
  • Molecular Weight 177.12
  • Synonym(s) 6-Methyl-4-(trifluoromethyl)pyridin-2-ol, 1,2-Dihydro-6-methyl-2-oxo-4-(trifluoromethyl)pyridine
  • SMILES O=C1C=C(C(F)(F)F)C=C(C)N1

Description

6-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the methyl substituent at C6 modulates reactivity. This heterocyclic scaffold integrates readily into bioactive molecules, offering favorable solubility and robustness under standard bench conditions for medicinal chemistry applications.

Application

6-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. Its electron-deficient pyridinone core facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides a handle for further functionalization. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows for API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501

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Computational Chemistry Data

  • TPSA   32.86
  • LogP   1.70212
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   0

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