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Structure of 22123-19-9
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6-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one features a trifluoromethyl group that enhances electron deficiency and metabolic stability, while the methyl substituent at C6 modulates reactivity. This heterocyclic scaffold integrates readily into bioactive molecules, offering favorable solubility and robustness under standard bench conditions for medicinal chemistry applications.
6-Methyl-4-(trifluoromethyl)pyridin-2(1H)-one serves as a versatile building block in medicinal chemistry, enabling efficient access to substituted pyridine scaffolds. Its electron-deficient pyridinone core facilitates nucleophilic substitution and transition-metal-catalyzed coupling reactions. The trifluoromethyl group enhances metabolic stability and lipophilicity, while the methyl substituent provides a handle for further functionalization. Bench-stable and readily purified by recrystallization, it functions effectively in standard synthetic workflows for API development.
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GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362-P405-P501
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Lot numbers can be found on the outside label of a product: