((2S,4R)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol

Name: ((2S,4R)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol
Brand: ChemScene
Availability: InStock
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CAS No. 2206737-78-0
Cat. No. CS-0146913
Purity≥98%
MDL No.None

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((2S,4R)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol|CS-0146913

Structure of 2206737-78-0

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Description

This fluorinated pyrrolidine derivative integrates a chiral methylated scaffold with a reactive hydroxyl group, enabling precise functionalization in medicinal chemistry. The (2S,4R) stereochemistry ensures high enantioselectivity in downstream transformations, while the bench-stable fluorine substituent enhances metabolic resilience. This compound serves as a key building block for CNS-targeted therapeutics and bioactive heterocycles.

Application

((2S,4R)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol serves as a versatile chiral building block in medicinal chemistry, enabling the construction of fluorinated pyrrolidine scaffolds prevalent in bioactive molecules. Its bench-stable nature and compatibility with standard coupling and functionalization protocols facilitate efficient synthesis of peptide mimetics and kinase inhibitors. The molecule’s defined stereochemistry and fluorine substitution enhance metabolic stability and membrane permeability, offering practical advantages in lead optimization workflows.

General Information

CAS No. 2206737-78-0
Cat. No. CS-0146913
Purity ≥98%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₂FNO
Molecular Weight 133.16
Synonym(s) [(2S,4R)-4-fluoro-1-methyl-pyrrolidin-2-yl]methanol
SMILES OC[C@H]1N(C)C[C@H](F)C1

Computational Chemistry Data

TPSA 23.47
LogP 0.0209
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

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Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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((2S,4R)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol

CAS No. 2206737-78-0

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