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Structure of 1138324-48-7
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This chiral pyrrolidine derivative features a tert-butyl ester and fluorinated ring, offering enhanced metabolic stability and stereochemical integrity. The hydroxymethyl group enables downstream functionalization, while the fluorine atom imparts favorable electronic and conformational properties. Designed for efficient integration into complex molecular architectures, this building block supports streamlined synthesis in medicinal chemistry and peptide modification workflows.
(2S,4R)-tert-Butyl 4-fluoro-2-(hydroxymethyl)pyrrolidine-1-carboxylate serves as a stereochemically defined pyrrolidine building block with orthogonal functional handles: a latent aldehyde via oxidation of the hydroxymethyl group and a reactive fluorine for nucleophilic substitution. Its tert-butyl carbamate protection ensures bench stability and compatibility with diverse coupling conditions. The molecule facilitates efficient access to bioactive heterocycles in medicinal chemistry campaigns, particularly in peptidomimetic and kinase inhibitor scaffolds.
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: