((2S,4S)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol

Name: ((2S,4S)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol
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CAS No. 1932616-77-7
Cat. No. CS-0159078
Molecule weight133.16
Purity≥95%
MDL No.None

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((2S,4S)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol|CS-0159078

Structure of 1932616-77-7

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General Information

CAS No. 1932616-77-7
Cat. No. CS-0159078
Purity ≥95%
MDL No. None
Storage 4°C, protect from light
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₆H₁₂FNO
Molecular Weight 133.16
Synonym(s) None
SMILES CN1[C@H](CO)C[C@H](F)C1

Description

This chiral pyrrolidinol derivative features a fluorinated, methyl-substituted ring system that enhances metabolic stability and membrane permeability. The pendant hydroxymethyl group enables direct functionalization or conjugation in synthetic routes. This scaffold integrates readily into bioactive molecules, particularly in CNS-targeted pharmaceutical development, where its steric profile and polarity support target engagement.

Application

((2S,4S)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol serves as a versatile chiral building block in medicinal chemistry, enabling the construction of fluorinated pyrrolidine scaffolds found in bioactive molecules. Its bench-stable nature and compatibility with standard coupling and functionalization protocols facilitate efficient synthesis of targeted analogs. The presence of both hydroxyl and methyl groups provides orthogonal handles for derivatization, while the stereochemistry ensures predictable stereochemical outcomes in downstream transformations.

Safety Information

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GHS Pictogram : N/A	GHS No : N/A
Signal Word : N/A	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

TPSA 23.47
LogP 0.0209
H_Acceptors 2
H_Donors 1
Rotatable_Bonds 1

Other Classifications

Building Blocks Functional Group Fluoride

Building Blocks Skeleton Aliphatic heterocycle compounds Pyrrolidine compounds

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Key Words

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((2S,4S)-4-Fluoro-1-methylpyrrolidin-2-yl)methanol

CAS No. 1932616-77-7

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