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CS-W001157 4
Total: USD 88.00

6-Fluoro-1-methylindolin-2-one

  • CAS No. 913240-15-0

  • Cat. No. CS-0310897
  • Molecule weight165.16
  • Purity≥98%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

6-Fluoro-1-methylindolin-2-one|CS-0310897

Structure of 913240-15-0

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General Information

  • CAS No. 913240-15-0
  • Cat. No. CS-0310897
  • Purity ≥98%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₉H₈FNO
  • Molecular Weight 165.16
  • Synonym(s) None
  • SMILES O=C1N(C)C2=C(C=CC(F)=C2)C1

Description

6-Fluoro-1-methylindolin-2-one is a fluorinated indolinone derivative featuring a reactive carbonyl group and a strategically positioned fluorine atom. This scaffold delivers enhanced metabolic stability and modulated electronic properties, making it valuable in medicinal chemistry for constructing bioactive molecules. The methyl substitution improves lipophilicity and binding affinity in target-directed synthesis.

Application

6-Fluoro-1-methylindolin-2-one serves as a versatile building block in medicinal chemistry, enabling efficient access to bioactive indolinone scaffolds. Its fluorinated aryl ring enhances metabolic stability and modulates electronic properties, while the N-methyl amide functionality provides favorable solubility and reactivity in coupling and functionalization reactions. The compound exhibits excellent bench stability and is compatible with standard synthetic transformations, facilitating rapid diversification for drug discovery applications.

Safety Information

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GHS Pictogram : N/A
GHS No : N/A
Signal Word : N/A
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : N/A
Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   20.31
  • LogP   1.3446
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   0

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