Lot numbers can be found on the outside label of a product:
N-Methyltetrahydro-2H-pyran-4-amine
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CAS No. 220641-87-2
- Cat. No. CS-D1570
- Purity≥98%
- MDL No.MFCD06658492
*For research and further manufacturing use only, not for direct human use.
Structure of 220641-87-2
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General Information
- CAS No. 220641-87-2
- Cat. No. CS-D1570
- Purity ≥98%
- MDL No. MFCD06658492
- Storage 4°C, protect from light
- Shipping Room temperature in continental US; may vary elsewhere.
- Molecular Formula C₆H₁₃NO
- Molecular Weight 115.17
- Synonym(s) 4-(Methylamino)tetrahydropyran; Methyl(tetrahydropyran-4-yl)amine; N-(Tetrahydropyran-4-yl)methylamine; N-Methyl(tetrahydropyran-4-yl)amine; N-METHYL-TETRAHYDRO-2H-PYRAN-4-AMINE HYDROCHLORIDE
- SMILES CNC1CCOCC1
Description
N-Methyltetrahydro-2H-pyran-4-amine is a bench-stable, moisture-tolerant amine featuring a tetrahydropyran ring that enhances solubility and metabolic stability. This tertiary amine integrates readily into bioactive scaffolds, offering improved membrane permeability and reduced basicity compared to simple alkylamines.
Application
N-Methyltetrahydro-2H-pyran-4-amine serves as a versatile building block in medicinal chemistry, enabling efficient access to saturated heterocyclic scaffolds. Its tertiary amine functionality offers favorable solubility and metabolic stability, while the tetrahydropyran ring provides conformational rigidity useful in structure-activity studies. The compound functions effectively in standard amine coupling reactions and exhibits bench stability under ambient conditions, facilitating straightforward handling and purification.
Synthesis
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Route1
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In-stock
38041-19-9 -
50-00-0 - ~%
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In-stock
220641-87-2
References
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WO2007/84786 A1, ; Page/Page column 136 ; WO 2007/084786 A1
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Route2
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In-stock
29943-42-8 -
25895-60-7
- ~%
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In-stock
220641-87-2
References
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US6277790 B1, ;
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Route3
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In-stock
29943-42-8
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593-51-1
- ~95%
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In-stock
220641-87-2
References
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Hashimoto, Hideo; Ikemoto, Tomomi; Itoh, Tatsuya; Maruyama, Hideaki; Hanaoka, Tadashi; Wakimasu, Mitsuhiro; Mitsudera, Hiroyuki; Tomimatsu, Kiminori Organic Process Research and Development, 2002 , vol. 6, # 1 p. 70 - 73
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Safety Information
Download SDS|
GHS Pictogram :
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GHS No : GHS07
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Signal Word : Warning
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UN#: N/A
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Class : N/A
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Packing Group : N/A
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Hazard Statements : H302-H315-H319-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
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Quality Control
Computational Chemistry Data
- TPSA 21.26
- LogP 0.3848
- H_Acceptors 2
- H_Donors 1
- Rotatable_Bonds 1
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Key Words
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