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Structure of 220227-80-5
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2-(2,4,6-Trifluorophenyl)acetonitrile features a trifluorophenyl group that imparts enhanced electron-withdrawal and metabolic stability. This aryl nitrile integrates readily into synthetic sequences requiring a robust, polarizable handle. The molecule exhibits excellent bench stability and solubility in common organic solvents, enabling seamless incorporation into pharmaceutical intermediates and functional materials.
2-(2,4,6-Trifluorophenyl)acetonitrile serves as a versatile building block in medicinal chemistry, enabling the synthesis of fluorinated arylalkyl scaffolds via standard coupling and functionalization reactions. Its trifluorophenyl moiety enhances metabolic stability and lipophilicity, while the nitrile group provides a handle for nucleophilic transformations and amide formation. The compound exhibits good bench stability and is compatible with common reaction conditions, facilitating efficient purification and integration into multi-step syntheses.
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GHS No : GHS06
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Signal Word : Danger
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UN#: 3276
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Class : 6.1
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Packing Group : Ⅲ
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Hazard Statements : H302-H312-H315-H319-H331-H335
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Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P361+P364-P403+P233-P405-P501
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Lot numbers can be found on the outside label of a product: