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CS-W001157 4
Total: USD 88.00

2,4,6-Trifluorobenzaldehyde

  • CAS No. 58551-83-0

  • Cat. No. CS-W007884
  • Purity≥97%
  • MDL No.MFCD00061197

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trifluorobenzaldehyde|CS-W007884

Structure of 58551-83-0

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General Information

  • CAS No. 58551-83-0
  • Cat. No. CS-W007884
  • Purity ≥97%
  • MDL No. MFCD00061197
  • Storage 4°C, stored under nitrogen
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₃F₃O
  • Molecular Weight 160.09
  • Synonym(s) 2,4,6-trifluoro benzaldehyde; 2,4,6-Trifluorobenzaldehyde
  • SMILES C1=C(C(=C(C=C1F)F)C=O)F

Description

2,4,6-Trifluorobenzaldehyde features a highly electron-deficient aromatic ring due to three fluorine substituents in the 2,4,6-positions. This strong inductive withdrawal enhances electrophilicity at the carbonyl carbon, enabling efficient nucleophilic addition reactions. The compound exhibits excellent bench stability and compatibility with moisture-sensitive transformations. It serves as a key building block for pharmaceutical intermediates and functional materials requiring fluorinated aromatic motifs.

Application

2,4,6-Trifluorobenzaldehyde serves as a valuable building block in medicinal chemistry and agrochemical synthesis, offering enhanced electrophilicity at the carbonyl due to strong electron-withdrawing effects of the trifluoromethyl groups. Its bench-stable nature and compatibility with nucleophilic addition reactions facilitate efficient access to diverse heterocyclic scaffolds and functionalized aryl derivatives under standard reaction conditions.

Synthesis

  • Route1
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      372-38-3
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      68-12-2
    • ~%
    • In-stock
      2,4,6-Trifluorobenzaldehyde|CS-W007884
      58551-83-0

    References

    • Journal of Medicinal Chemistry, , vol. 39, # 21 p. 4261 - 4274

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362+P364

Quality Control

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Computational Chemistry Data

  • TPSA   17.07
  • LogP   1.9164
  • H_Acceptors   1
  • H_Donors   0
  • Rotatable_Bonds   1

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