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CS-W001157 4
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2,4,6-Trifluorbenzyl alcohol

  • CAS No. 118289-07-9

  • Cat. No. CS-0196539
  • Purity≥98%
  • MDL No.MFCD00061207

*For research and further manufacturing use only, not for direct human use.

2,4,6-Trifluorbenzyl alcohol|CS-0196539

Structure of 118289-07-9

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General Information

  • CAS No. 118289-07-9
  • Cat. No. CS-0196539
  • Purity ≥98%
  • MDL No. MFCD00061207
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅F₃O
  • Molecular Weight 162.11
  • Synonym(s) None
  • SMILES C1=C(C=C(C(=C1F)CO)F)F

Description

2,4,6-Trifluorbenzyl alcohol features a trifluoromethyl-substituted benzyl scaffold with enhanced electron-withdrawing character, enabling robust functionalization in cross-coupling and conjugation reactions. The hydroxyl group provides a handle for derivatization while maintaining stability under standard bench conditions.

Application

2,4,6-Trifluorobenzyl alcohol serves as a versatile building block in medicinal chemistry, enabling efficient incorporation of trifluoromethylaryl motifs into target molecules. Its bench-stable nature and compatibility with diverse transformations—such as oxidation to the aldehyde, coupling reactions, and derivatization—facilitate rapid access to functionalized scaffolds. The electron-withdrawing trifluoromethyl groups enhance metabolic stability and modulate lipophilicity, making it particularly valuable for optimizing pharmacokinetic profiles in API development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

Quality Control

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Computational Chemistry Data

  • TPSA   20.23
  • LogP   1.5962
  • H_Acceptors   1
  • H_Donors   1
  • Rotatable_Bonds   1

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