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Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid

  • CAS No. 378211-85-9

  • Cat. No. CS-0133047
  • Purity≥97%
  • MDL No.MFCD00297221

*For research and further manufacturing use only, not for direct human use.

Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid|CS-0133047

Structure of 378211-85-9

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General Information

  • CAS No. 378211-85-9
  • Cat. No. CS-0133047
  • Purity ≥97%
  • MDL No. MFCD00297221
  • Storage 4°C
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₇H₅N₃O₂
  • Molecular Weight 163.13
  • Synonym(s) Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid (9CI)
  • SMILES O=C(C1=NN2C=CC=NC2=C1)O

Description

Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid features a fused heterocyclic core with a carboxylic acid group at the 2-position, enabling direct conjugation or derivatization. This scaffold combines electron-deficient aromaticity with hydrogen-bonding capacity, offering utility in medicinal chemistry and materials science applications.

Application

Pyrazolo[1,5-a]pyrimidine-2-carboxylic acid serves as a versatile heterocyclic building block in medicinal chemistry, enabling the synthesis of bioactive scaffolds through standard coupling reactions. Its carboxylic acid functionality facilitates direct derivatization or amide formation under mild conditions, while the fused pyrazolo[1,5-a]pyrimidine core exhibits good bench stability and functional group tolerance. This compound functions as a key intermediate in the construction of kinase inhibitors and other pharmacologically relevant architectures.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   67.49
  • LogP   0.4275
  • H_Acceptors   4
  • H_Donors   1
  • Rotatable_Bonds   1

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