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CS-W001157 4
Total: USD 88.00

6-Chloro-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid

  • CAS No. 38076-76-5

  • Cat. No. CS-W019669
  • Purity≥97%
  • MDL No.MFCD18343615

*For research and further manufacturing use only, not for direct human use.

6-Chloro-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid|CS-W019669

Structure of 38076-76-5

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General Information

  • CAS No. 38076-76-5
  • Cat. No. CS-W019669
  • Purity ≥97%
  • MDL No. MFCD18343615
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₆H₄ClNO₃
  • Molecular Weight 173.55
  • Synonym(s) 6-chloro-2-oxo-1,2-dihydropyridine-3-carboxylic acid
  • SMILES O=C(C1=CC=C(Cl)NC1=O)O

Description

6-Chloro-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid features a chlorinated pyridone core that enhances electronic withdrawal and metabolic stability. This scaffold integrates readily into medicinal chemistry campaigns targeting kinase inhibitors and antimicrobial agents, offering improved solubility and predictable reactivity under standard conditions.

Application

6-Chloro-1,2-dihydro-2-oxo-3-pyridinecarboxylic acid serves as a versatile building block for pyridine-based heterocycles, enabling efficient access to medicinally relevant scaffolds. Its chlorine substituent facilitates nucleophilic aromatic substitution and palladium-catalyzed coupling reactions, while the carboxylic acid group supports direct derivatization or activation for amide bond formation. The compound exhibits good bench stability and compatibility with standard synthetic workflows, making it suitable for iterative synthesis in medicinal chemistry and process development.

Safety Information

Download SDS
GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   70.42
  • LogP   1.1388
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   1

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