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Acid-PEG2-C2-Boc

  • CAS No. 2086688-99-3

  • Cat. No. CS-0114419
  • Purity≥98%
  • MDL No.MFCD30723272

*For research and further manufacturing use only, not for direct human use.

Acid-PEG2-C2-Boc|CS-0114419

Structure of 2086688-99-3

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General Information

  • CAS No. 2086688-99-3
  • Cat. No. CS-0114419
  • Purity ≥98%
  • MDL No. MFCD30723272
  • Storage 4°C, sealed storage, away from moisture
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₂H₂₂O₆
  • Molecular Weight 262.30
  • Synonym(s) None
  • SMILES O=C(OC(C)(C)C)CCOCCOCCC(O)=O

Description

Acid-PEG2-C2-Boc features a carboxylic acid terminus linked to a short PEG spacer and a C2 chain, terminating in a Boc-protected amine. This bifunctional reagent enables site-specific conjugation in peptide synthesis and biomolecule labeling, offering enhanced solubility and stability under standard conditions.

Application

Acid-PEG2-C2-Boc serves as a versatile, bench-stable building block for the synthesis of PEGylated conjugates. The carboxylic acid group enables efficient coupling with amines under standard conditions, while the Boc-protected amine offers orthogonal functionality for selective deprotection. This dual-functional design facilitates modular assembly of bioconjugates and prodrugs, with excellent solubility and purification compatibility in aqueous and organic media.

Safety Information

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Precautionary Statements : N/A

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Computational Chemistry Data

  • TPSA   82.06
  • LogP   1.2261
  • H_Acceptors   5
  • H_Donors   1
  • Rotatable_Bonds   9

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