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(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-2-methylpropanoic acid

  • CAS No. 207117-28-0

  • Cat. No. CS-0134894
  • Purity≥95%
  • MDL No.MFCD02682594

*For research and further manufacturing use only, not for direct human use.

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-2-methylpropanoic acid|CS-0134894

Structure of 207117-28-0

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General Information

  • CAS No. 207117-28-0
  • Cat. No. CS-0134894
  • Purity ≥95%
  • MDL No. MFCD02682594
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₁₉H₁₉NO₅
  • Molecular Weight 341.36
  • Synonym(s) N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-2-methyl-L-serine
  • SMILES OC[C@](C(O)=O)(C)NC(OCC1C2=C(C3=C1C=CC=C3)C=CC=C2)=O

Description

This fluorenylmethoxycarbonyl-protected amino acid derivative features a chiral center at the alpha position, enabling stereoselective incorporation into peptide chains. The pendant hydroxyl group offers a handle for further functionalization, while the fluorenylmethoxycarbonyl moiety provides robust protection under standard coupling conditions.

Application

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-hydroxy-2-methylpropanoic acid serves as a protected chiral building block for peptide synthesis, enabling efficient incorporation of hydroxylated amino acid motifs. The Fmoc group provides orthogonal protection with high stability under basic conditions and facilitates facile deprotection. The tertiary alcohol functionality offers a site for selective derivatization, while the methyl-substituted α-carbon enhances steric control in coupling reactions. Its bench-stable crystalline form simplifies handling and purification in standard synthetic workflows.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   95.86
  • LogP   2.3607
  • H_Acceptors   4
  • H_Donors   3
  • Rotatable_Bonds   5

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