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CS-W001157 4
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Fmoc-(S)-3-amino-4-(3-chlorophenyl)-butyric acid

  • CAS No. 270596-40-2

  • Cat. No. CS-0061693
  • Purity≥97%
  • MDL No.MFCD01861000

*For research and further manufacturing use only, not for direct human use.

Fmoc-(S)-3-amino-4-(3-chlorophenyl)-butyric acid|CS-0061693

Structure of 270596-40-2

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General Information

  • CAS No. 270596-40-2
  • Cat. No. CS-0061693
  • Purity ≥97%
  • MDL No. MFCD01861000
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₂ClNO₄
  • Molecular Weight 435.90
  • Synonym(s) N-BETA-(9-FLUORENYLMETHOXYCARBONYL)-L-BETA-HOMO(3-CHLOROPHENYL)ALANINE
  • SMILES ClC1=CC=CC(C[C@@H](CC(O)=O)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)=C1

Description

Fmoc-(S)-3-amino-4-(3-chlorophenyl)-butyric acid is a bench-stable, moisture-tolerant amino acid derivative featuring a para-chlorinated phenyl group and a protected α-amino function. This building block integrates seamlessly into peptide synthesis workflows, enabling efficient access to bioactive sequences with enhanced hydrophobicity and metabolic stability.

Application

Fmoc-(S)-3-amino-4-(3-chlorophenyl)-butyric acid serves as a versatile building block for the synthesis of bioactive peptides and peptidomimetics. The Fmoc group enables efficient solid-phase peptide synthesis, while the 3-chlorophenyl moiety imparts enhanced lipophilicity and metabolic stability. This amino acid derivative exhibits excellent bench stability, facilitates straightforward purification, and tolerates common coupling conditions, making it well-suited for iterative synthesis workflows in medicinal chemistry and API development.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P260-P264-P270-P271-P280-P301+P310-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P337+P313-P362+P364-P403+P233-P405-P501

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   5.2645
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   7

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