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CS-W001157 4
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Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid

  • CAS No. 181953-60-6

  • Cat. No. CS-0182704
  • Purity≥97%
  • MDL No.None

*For research and further manufacturing use only, not for direct human use.

Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid|CS-0182704

Structure of 181953-60-6

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General Information

  • CAS No. 181953-60-6
  • Cat. No. CS-0182704
  • Purity ≥97%
  • MDL No. None
  • Storage Store at room temperature
  • Shipping Room temperature in continental US; may vary elsewhere.
  • Molecular Formula C₂₅H₂₀F₃NO₄
  • Molecular Weight 455.43
  • Synonym(s) 3-(Fmoc-amino)-3-(3-trifluoromethylphenyl)propanoic acid
  • SMILES O=C(NC(CC(O)=O)C1=CC=CC(C(F)(F)F)=C1)OCC2C3=C(C4=C2C=CC=C4)C=CC=C3

Description

Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)-propionic acid is a chiral building block featuring a trifluoromethyl-substituted phenyl group and a robust Fmoc-protected amine. This moiety integrates readily into peptide synthesis workflows, offering enhanced solubility and stability under standard conditions. The electron-withdrawing trifluoromethyl group modulates electronic properties, facilitating downstream functionalization in medicinal chemistry applications.

Application

Fmoc-(RS)-3-amino-3-(3-trifluoromethylphenyl)propionic acid serves as a versatile building block for peptide synthesis, enabling the incorporation of a hydrophobic, electron-withdrawing trifluoromethylphenyl side chain. The Fmoc group provides orthogonal protection for primary amines, facilitating standard solution-phase and solid-phase peptide coupling protocols. Its stability under basic conditions and compatibility with diverse coupling reagents make it well-suited for robust, high-yield syntheses in medicinal chemistry and peptide-based drug discovery.

Safety Information

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GHS Pictogram :
GHS No : GHS07
Signal Word : Warning
UN#: N/A
Class : N/A
Packing Group : N/A
Hazard Statements : H315-H319
Precautionary Statements : P264-P280-P302+P352-P362+P364

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Computational Chemistry Data

  • TPSA   75.63
  • LogP   5.7599
  • H_Acceptors   3
  • H_Donors   2
  • Rotatable_Bonds   6

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