(9H-Fluoren-9-yl)MethOxy]Carbonyl L-4-Acetylphe

Name: (9H-Fluoren-9-yl)MethOxy]Carbonyl L-4-Acetylphe
Brand: ChemScene
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CAS No. 204716-07-4
Cat. No. CS-0179063
Purity≥96%
MDL No.MFCD01317022

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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(9H-Fluoren-9-yl)MethOxy]Carbonyl L-4-Acetylphe|CS-0179063

Structure of 204716-07-4

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General Information

CAS No. 204716-07-4
Cat. No. CS-0179063
Purity ≥96%
MDL No. MFCD01317022
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₆H₂₃NO₅
Molecular Weight 429.46
Synonym(s) Fmoc-4-Acetyl-DL-phenylalanine
SMILES CC(C1=CC=C(C[C@H](NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O)C(O)=O)C=C1)=O

Description

Fmoc-L-4-acetylphe is a protected amino acid derivative featuring a fluorenylmethoxy carbonyl (Fmoc) group at the N-terminus and an acetyl-modified side chain on the phenylalanine moiety. This combination enables stable incorporation into peptide synthesis workflows, where the Fmoc group facilitates orthogonal deprotection under mild basic conditions. The acetyl substitution enhances metabolic stability in bioactive peptide sequences.

Application

L-4-Acetylphe-(9H-Fluoren-9-yl)methyl ester serves as a stable, bench-ready amino acid building block for peptide synthesis. The fluorenylmethoxycarbonyl (Fmoc) group enables efficient orthogonal protection, while the acetyl side chain provides modulated reactivity and enhanced solubility. This derivative facilitates smooth coupling reactions, minimizes racemization, and simplifies purification—ideal for iterative solid-phase and solution-phase methodologies in medicinal chemistry workflows.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 92.7
LogP 4.4236
H_Acceptors 4
H_Donors 2
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Functional Group Ketone

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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(9H-Fluoren-9-yl)MethOxy]Carbonyl L-4-Acetylphe

CAS No. 204716-07-4

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