Fmoc-Phe(3-CONH2)-OH

Name: Fmoc-Phe(3-CONH2)-OH
Brand: ChemScene
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CAS No. 959573-22-9
Cat. No. CS-0137322
Purity≥97%
MDL No.MFCD06659144

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
Accessible (Haz class 3, 4, 5 or 8), International	$238.00+

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General Information

CAS No. 959573-22-9
Cat. No. CS-0137322
Purity ≥97%
MDL No. MFCD06659144
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₂N₂O₅
Molecular Weight 430.45
Synonym(s) Fmoc-L-3-Carbamoylphe
SMILES O=C(O)[C@H](CC1=CC=CC(C(N)=O)=C1)NC(OCC2C3=C(C4=C2C=CC=C4)C=CC=C3)=O

Description

Fmoc-Phe(3-CONH2)-OH features a para-amino substituent on the phenyl ring, enhancing solubility and modulating electronic properties for optimized coupling efficiency. This derivative integrates seamlessly into peptide synthesis workflows, offering improved handling and reduced aggregation during chain elongation.

Application

Fmoc-Phe(3-CONH2)-OH serves as a key building block for the synthesis of peptide libraries and bioactive oligomers, featuring a meta-substituted phenylalanine derivative with a C-terminal amide. The Fmoc group enables efficient N-terminal protection in solid-phase peptide synthesis, while the 3-carboxamide functionality provides enhanced solubility and metabolic stability. This compound exhibits excellent bench stability, tolerates standard coupling conditions, and facilitates orthogonal functionalization in complex sequence assembly.

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H315-H319-H335
Precautionary Statements : P261-P280-P302+P352

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Computational Chemistry Data

TPSA 118.72
LogP 3.3199
H_Acceptors 4
H_Donors 3
Rotatable_Bonds 7

Other Classifications

Building Blocks Functional Group Fmoc

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Chemical Biology Peptide Chemistry Amine Protection

Chemical Biology Peptide Chemistry Unnatural Amino Acid Derivatives

Key Words

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Fmoc-Phe(3-CONH2)-OH

CAS No. 959573-22-9

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