Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionic acid

Name: Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionic acid
Brand: ChemScene
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CAS No. 507472-20-0
Cat. No. CS-0179101
Purity≥98%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
Hazmat Ground shipping	$50.00+
Inaccessible (Haz class 6.1 or 9), Domestic	$68.00+
Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
Inaccessible (Haz class 6.1 or 9), International	$108.00+
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Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionic acid|CS-0179101

Structure of 507472-20-0

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General Information

CAS No. 507472-20-0
Cat. No. CS-0179101
Purity ≥98%
MDL No. None
Storage Store at room temperature
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₂₅H₂₀F₃NO₄
Molecular Weight 455.43
Synonym(s) Fmoc-S-3-Amino-3-(3-trifluoromethyl-phenyl)-propionic acid
SMILES O=C(O)C[C@@H](C1=CC(C(F)(F)F)=CC=C1)NC(OCC2C3=CC=CC=C3C4=CC=CC=C42)=O

Description

Fmoc-(S)-3-Amino-3-(3-trifluoromethylphenyl)propionic acid is a trifluoromethyl-substituted amino acid derivative designed for peptide synthesis. The electron-withdrawing trifluoromethyl group enhances solubility and metabolic stability in biologically active sequences. This building block integrates readily into C-terminal extensions, enabling precise incorporation of hydrophobic, fluorinated motifs into therapeutic peptides under standard coupling conditions.

Application

Fmoc-(S)-3-Amino-3-(3-trifluoromethylphenyl)propionic acid serves as a valuable building block for the synthesis of peptide conjugates and bioactive scaffolds. The Fmoc group enables efficient solid-phase peptide synthesis, while the para-trifluoromethylphenyl moiety imparts enhanced metabolic stability and lipophilicity. This amino acid derivative exhibits excellent bench stability, tolerates diverse reaction conditions, and facilitates straightforward purification—making it ideal for iterative coupling workflows in medicinal chemistry and chemical biology applications.

Safety Information

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GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302-H312-H332
Precautionary Statements : P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

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Computational Chemistry Data

TPSA 75.63
LogP 5.7599
H_Acceptors 3
H_Donors 2
Rotatable_Bonds 6

Other Classifications

Building Blocks Functional Group Amine

Building Blocks Functional Group Fluoride

Building Blocks Functional Group Carboxylic Acid

Building Blocks Skeleton Chiral compounds Chiral Building Blocks

Building Blocks Skeleton Aromatic ring compounds Benzene compounds

Key Words

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Fmoc-(S)-3-Amino-3-(3-trifluoromethyl-phenyl)-propionic acid

CAS No. 507472-20-0

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