Methyl 4-chloro-6-methoxypicolinate

Name: Methyl 4-chloro-6-methoxypicolinate
Brand: ChemScene
Availability: InStock
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CAS No. 204378-37-0
Cat. No. CS-0187504
Purity≥95%
MDL No.None

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Type	HazMat Fee
Excepted Quantity	$0.00
FedEx Limited Quantities Ground	$0.00
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Accessible (Haz class 3, 4, 5 or 8), Domestic	$158.00+
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Methyl 4-chloro-6-methoxypicolinate|CS-0187504

Structure of 204378-37-0

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General Information

CAS No. 204378-37-0
Cat. No. CS-0187504
Purity ≥95%
MDL No. None
Storage 4°C
Shipping Room temperature in continental US; may vary elsewhere.
Molecular Formula C₈H₈ClNO₃
Molecular Weight 201.61
Synonym(s) 4-chloro-6-methoxypicolinic acid methyl ester
SMILES COC1=CC(=CC(=N1)C(=O)OC)Cl

Description

Methyl 4-chloro-6-methoxypicolinate features a pyridine core with orthogonal electron-withdrawing chlorine and electron-donating methoxy groups, enabling precise tuning of reactivity. This bench-stable ester integrates readily into synthetic sequences requiring regioselective functionalization or serves as a key intermediate in bioactive compound development.

Application

Methyl 4-chloro-6-methoxypicolinate serves as a versatile building block in medicinal chemistry, enabling efficient construction of substituted pyridine scaffolds. The chloro group facilitates nucleophilic substitution reactions, while the methyl ester supports selective reduction or functionalization. Its bench-stable nature and compatibility with standard coupling protocols make it well-suited for modular synthesis workflows targeting bioactive heterocycles.

Synthesis

Route1
- In-stock
  
  1008304-85-5
- ~%
- In-stock
  
  204378-37-0
References
- HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd Patent: US2013/158042 A1, 2013 ;
Route2
- In-stock
  
  2587-02-2
- ~%
- In-stock
  
  204378-37-0
References
- HEIMANN, Annekatrin; DAHMANN, Georg; GRUNDL, Marc; MUELLER, Stephan Georg; WELLENZOHN, Bernd Patent: US2013/158042 A1, 2013 ;

Safety Information

Download SDS

GHS Pictogram :	GHS No : GHS07
Signal Word : Warning	UN#: N/A
Class : N/A	Packing Group : N/A
Hazard Statements : H302
Precautionary Statements : P264-P270-P330

Quality Control

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Computational Chemistry Data

TPSA 48.42
LogP 1.5302
H_Acceptors 4
H_Donors 0
Rotatable_Bonds 2

Other Classifications

Building Blocks Functional Group Ester

Building Blocks Skeleton Aromatic heterocycle compounds Pyridine compounds

Key Words

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Methyl 4-chloro-6-methoxypicolinate

CAS No. 204378-37-0

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